Experimental Models of COVID-19

Experimental Models of COVID-19

Blog Article

COVID-19 is the most consequential pandemic of the 21st century.Since the earliest stage of the 2019-2020 epidemic, animal models have been useful in understanding the etiopathogenesis of SARS-CoV-2 infection and rapid development of vaccines/drugs to prevent, treat or eradicate SARS-CoV-2 infection.Early SARS-CoV-1 research using immortalized in-vitro cell lines have aided in understanding different cells and receptors needed for SARS-CoV-2 infection and, due to their ability to be easily manipulated, continue to broaden our understanding of COVID-19 disease in in-vivo models.The scientific community determined animal models as the most useful models which could demonstrate viral infection, replication, Advanced Wound Care - Silicone transmission, and spectrum of illness as seen in human populations.Until now, there have not been well-described animal models of SARS-CoV-2 infection although transgenic mouse models (i.

e.mice with humanized ACE2 receptors with humanized receptors) have been proposed.Additionally, there are only limited facilities (Biosafety level 3 laboratories) available to contribute research to aid in eventually exterminating SARS-CoV-2 infection around the world.This review summarizes the most successful animal models of SARS-CoV-2 infection including studies in Non-Human Primates (NHPs) which were found to be susceptible to infection and transmitted the virus similarly to humans (e.g.

, Rhesus macaques, Cynomolgus, and African Green Monkeys), and animal models that do not require Biosafety level 3 laboratories (e.g., Mouse Hepatitis Virus models of COVID-19, Ferret model, Syrian Hamster model).Balancing safety, mimicking human COVID-19 and robustness of the animal model, the Murine Hepatitis Virus-1 Murine Baskets model currently represents the most optimal model for SARS-CoV-2/COVID19 research.Exploring future animal models will aid researchers/scientists in discovering the mechanisms of SARS-CoV-2 infection and in identifying therapies to prevent or treat COVID-19.